Legally Blonde had its pre-Broadway tryout at the Golden Gate Theatre in San Francisco beginning in previews on January 23, 2007, and playing its final performance in San Francisco on February 24, 2007. After some changes to the score and minor adjustments to the book, the show opened for previews on April 3, 2007. The Broadway production, directed and choreographed by Jerry Mitchell, opened on April 29, 2007 at the Palace Theatre to mostly positive reviews.

During the week ending June 24, 2007, Legally Blonde: The Musical hit a milestone by joining the millionaires' club for the weekly Broadway grosses, by grossing $1,003,282.

The musical was filmed for television on September 18, 2007 and was broadcast on the MTV network on October 13 and 14, 2007 with a subsequent air date on November 3 and 14, 2007 at 7pm.